Five Muscle-Building Supplements to Avoid for Optimal Gains

June 14, 2025
Five Muscle-Building Supplements to Avoid for Optimal Gains

In the pursuit of muscle growth, athletes and fitness enthusiasts often turn to dietary supplements for an edge. However, not all supplements are beneficial; some may even hinder progress. According to Roxana Ehsani, M.S., RD, CSSD, a registered dietitian and national media spokesperson, several commonly used supplements can do more harm than good. This article examines five muscle-building supplements that experts recommend avoiding, highlighting the reasons and potential risks associated with their use.

### Appetite Suppressants

Briana Butler, MCN, RDN, LD, emphasizes that appetite suppressants can undermine muscle gain. Active individuals require additional calories to support their workouts and subsequent muscle growth. Butler states, “It’s a common misconception that reducing food intake is essential for building muscle or improving body composition, but that's not necessarily true.” By stifling hunger cues, appetite suppressants can hinder nutrient intake necessary for muscle development, potentially leading to reduced growth or even muscle loss.

### Weight and Mass Gainers

Weight and mass gainers appear to be an easy solution for those struggling to increase muscle mass. However, Kelly Jones, M.S., RD, CSSD, warns that many of these products are high in saturated fats and calories while lacking essential nutrients. “Some mass gainers contain over 1,200 calories per serving and miss out on important vitamins and minerals,” Jones explains. Such supplements can lead to fat gain rather than muscle gain, further complicating fitness goals. Instead, she recommends focusing on nutrient-dense foods, including lean proteins and whole grains.

### High-Dose Antioxidant Supplements

Marie Spano, M.S., RD, cautions against high doses of antioxidant supplements, particularly vitamins C and E. Research suggests that chronic supplementation may inhibit muscle growth by interfering with the body's natural signaling processes essential for hypertrophy. Spano advises that athletes should prioritize obtaining antioxidants from a diverse diet rich in colorful fruits and vegetables instead of relying on supplements.

### Hormones or Prohormones

The allure of hormonal supplements or prohormones can be tempting for those seeking rapid results. However, Butler warns that these products can disrupt natural hormone production, potentially leading to adverse effects on long-term health. Although testosterone is crucial for muscle growth, the use of prohormones without medical supervision can lower HDL cholesterol levels and harm other organs. Butler emphasizes the importance of consulting healthcare professionals before considering such supplements.

### Pre-Workout Supplements

Pre-workout supplements are popular for their potential to enhance performance; however, Jones highlights the risks associated with their often unregulated ingredients. Many pre-workouts contain high levels of caffeine and niacin, which can lead to uncomfortable side effects such as flushing. “Instead, consider a simple cup of coffee, which has been linked to improved muscle strength and power without the added concerns,” Jones suggests.

### Conclusion

Building muscle is a gradual process that requires thoughtful nutrition and exercise. Experts agree that the pursuit of shortcuts through questionable supplements can be counterproductive. For personalized guidance on safe supplementation and nutrition, working with a sports dietitian is recommended. As the market for fitness supplements continues to grow, awareness of the potential risks associated with certain products remains critical for achieving health and fitness goals effectively.

As the fitness industry evolves, maintaining a focus on balanced nutrition and scientifically backed supplementation will be essential for athletes aiming to optimize their performance and health.

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muscle gaindietary supplementsappetite suppressantsweight gainersmass gainershigh-dose antioxidantshormonal supplementspre-workout supplementssports nutritionfitnessdietitiansBriana ButlerKelly JonesMarie SpanoRoxana Ehsaninutrient-dense foodsmuscle hypertrophydietary guidelinesexercise performancehealth risksnutritional advicepersonal trainersathletic performancesaturated fatscholesterolexercise sciencemuscle recoveryfitness misconceptionsnutritional supplementsscientific research

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