Physical Performance Correlates with Cognitive Function in MS Patients

A recent study conducted by researchers at the University of Eastern Finland has established a significant association between physical performance and cognitive function in patients with relapsing-remitting multiple sclerosis (MS). Published in the *Journal of Central Nervous System Disease* on July 8, 2025, the study highlights how improved physical capacity correlates with enhanced cognitive abilities in individuals diagnosed with this chronic neurological condition.

The research, led by Doctoral Researcher Marko Luostarinen, aimed to explore the intricate relationships among cognition, disability, and physical performance in patients suffering from relapsing-remitting MS. Cognitive impairment is a prevalent issue faced by MS patients, often impacting their quality of life and work capacity. According to Luostarinen, "Our results are interesting and support previous studies very well. Regular cognitive testing of patients with MS would be useful as part of the assessment of their disability and, for example, when making possible exercise recommendations."

The study utilized multiple measurement methodologies, including the six-minute walk test to assess physical performance, accelerometers for physical activity tracking, and standardized cognitive assessments such as the Symbol Digit Modalities Test (SDMT) and the Paced Auditory Serial Addition Test (PASAT). Disability levels were measured using the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC).

Key findings indicated that cognitive function, particularly skills related to information processing, was significantly impaired in patients exhibiting greater disability (EDSS over 2.5). Those with better walking test performance demonstrated superior cognitive function, particularly amongst patients categorized as having moderate disability (EDSS 3–5.5). Notably, while daily physical activity was linked to cognitive performance in healthy controls, this correlation was not evident among the MS patient group, suggesting a unique interaction between physical and cognitive health in this demographic.

The implications of these findings extend beyond individual health, highlighting broader societal impacts. Cognitive impairment not only affects personal well-being but also poses challenges in workforce participation for those with MS. The study underscores the need for further research to investigate the connections between cognition, functional capacity, and physical fitness across various MS patient types.

Additionally, the research aligns with previous literature indicating a crucial need for integrated care approaches in managing MS, where addressing cognitive health is as vital as treating physical symptoms. As the field progresses, incorporating regular cognitive assessments into patient care protocols may enhance overall treatment efficacy and promote better health outcomes.

In summary, the study from the University of Eastern Finland contributes valuable insights into the relationship between physical performance and cognitive function in MS patients, advocating for a more holistic approach to treatment that encompasses both physical and cognitive health. Future research will be essential to further elucidate these connections and explore potential interventions that could improve the quality of life for those affected by multiple sclerosis.